Skip to main content

Pleurodeles waltl salamander genome unlock secret of regeneration

The Salamander genome provides clues about unique regenerative abilities. The Karolinska Institutet research team in Sweden ranked the giant genome of the Pleurodeles waltl salamander six times larger than the human genome. A family of genes gives clues about the ability of regeneration of complex tissues.

The first sequence of the entire Iberian ribbed newt genome allows a new discovery of the ability of amphibians to regenerate brain neurons and all parts of the body. Among the findings are many copies of certain groups of microRNAs in which mammals are found in embryonic stem cells and also in tumor cells.

Tinuku Pleurodeles waltl salamander genome unlock secret of regeneration

"It is interesting to know how regeneration in adult organisms that reactivate embryonic genes. Need to do functional studies of microRNA molecules in regeneration and also link to cancer cells," says Professor András Simon at Karolinska Institutet.

Simon predicts a unique combination of genes within the salamanders and how other more common genes regulate and control the actual regeneration process is important in the abundance of stem cell microRNA genes. One of the reasons the salamander genome has not been sequenced due to technical and methodological challenges, the team reports Nature Communications.

"Only now is the technology available to handle such a large genome.The latest technology allows more efficient sorting," says Simon.

The team at Karolinska Institutet is now engaged with other researchers to explore new genomes and test new hypotheses through systematic comparisons with mammals that have been a major challenge for scientists worldwide.

"Ten years ago the salamanders were known to create all the dead cells in Parkinson's within four weeks, we are now going to investigate the underlying molecular processes. Our findings are expected to lead to the development of a new regenerative strategy for humans," said Simon.


Popular posts

European Union and ASEAN to restart Free Trade Agreement

Tinuku - European Union (EU) and ASEAN have agreed to restart the process of forming Free Trade Agreement (FTA). Singapore Prime Minister Lee Hsien Loong as ASEAN coordinator for EU-ASEAN relations said on Saturday to build a framework to identify potential sectors to finalize the deal.

Lee also said the EU and ASEAN had agreed to restart the process of establishing a free trade agreement between the two blocs. The EU and ASEAN launched talks towards a pact in 2007 but ignored the process two years later as the EU voted to negotiate bilaterally with each country.

"As coordinators, we look forward to forming a framework to identify where areas where we have the potential to make a deal," Lee said.

"Working on a deal may take longer than the end of the year. But if we can identify where the big opportunities are, our trade-offs, then I hope we will have better success," Lee said.

"One of the things we expect is that European nations are able to manage their soci…

Rolls-Royce plans for flying taxi service

Tinuku - Rolls-Royce Holdings plc has designed a propulsion system for flying taxi and is starting search for partners to help develop a project it hopes could take to the skies as soon as early next decade. British jet engine maker said on Sunday it had drawn up plans for an electric vertical take-off and landing (EVTOL) vehicle which could carry to five people at speeds of up 250 mph for approximately 500 miles.

The company joins a variety of companies racing to develop flying taxis, which could revolutionize the way people travel. Aviation and technology leaders are working to make electric-powered flying taxis a reality, including Airbus, U.S. ride- sharing firm Uber and a range of start-ups including one backed by Google co-founder Larry Page, called Kitty Hawk.

Rolls-Royce’s design will be showcased in digital form at the Farnborough Airshow, which starts on Monday. The company is looking for an airframer and a partner to provide aspects of the electrical system to help commerci…

Britain announced its first launch site for the space market

Tinuku - UK on Monday ran an important leap for the construction of the first vertical launch space launch site. The proposed space port at Sutherland in the north of Scotland has been awarded US$3.3 million in funding by the government-owned UK Space Agency to develop a ground-breaking launch site.

Government Business Secretary Greg Clark Monday launched the start of a Great British Space Age that will see vertically-launched space rockets and satellites take off from the new spaceport. UK Space Agency said it selected the Sutherland site because Scotland is the best place in Britain to reach highly sought-after satellite orbits with vertically launched rockets.

The initial funding will go to Scotland's Highlands and Islands Enterprise agency to develop the Sutherland site which will use a combination of proven and innovative rocket technologies to pave the way for a world-leading spaceflight market.

The UK Space Agency is also making available a new 2.65 million U.S. dollar fund…

Psychoengine studio build Honda GL 200 single-cylinder engine turns into Five Dragons 5-cylinder

Tinuku ~ Studio Psycoengine based in Purwokerto, Indonesia, building works Honda Tiger with a 5-cylinder rotary. Custom motorcycle entitled "Five Dragons" by M Yusuf Adib Mustofa emerged as the Best of the Best Kustomfest 2016 Legend Reborn.